TriVersa NanoMateGeneral DescriptionThe Advion TriVersa NanoMate is a chip-based electrospray ionization (ESI) source for mass spectrometry systems. ESI chips provide the power of mass spectrometry in an efficient size thanks to miniaturization.

An array of 400 nanotubules on each chip produces a precise, reliable spray due to the electric field created by each tube. This instrument integrates three different modes to accomplish this task, which includes operating as (1) a chip-based infusion ionizing source, (2) an LC/MS fraction collector with chip-based infusion, and (3) a liquid extraction surface analyzer (LESA). Each of these modes has its own benefits and ideal applications, giving the instrument great flexibility and value for sample mass analysis.Utilizing the chip-based infusion mode, which makes use of ESI chips displaying an array of very fine nanoelectrospray nozzles, allows for efficient and stable flow rates. These flow rates can be adjusted to anywhere from 20 to 200 nL/min.

. Manual operation. TriVersa NanoMate for Higher FlowsTriVersa NanoMate for Higher Flows 320um columns and above. Set-up TriVersa-NanoMate Fraction collection into 384 plates (or 96 plates) 240 µL/min incoming flow. Infusion using a Triversa Nanomate (Advion Biosciences. Advion COVID-19 Update Mass Spec Solutions for Chemical Biology Advion’s three-decade dedication to serving scientists through mass spectrometry has empowered labs across a wide range of applications to maximize time, space and efficiency with optimal, fit for purpose solutions. TriVersa NanoMate. Chip-Based Electrospray Ionization.

Infusion via this method is automated and, given the separation of each nanoelectrospray nozzle, has virtually no risk of sample-to-sample carryover. Need for speed underground 2 unlock everything pc mode. The standard use of ESI chip-based infusion lends itself well to applications in protein identification, lipid analysis, and investigations in noncovalent interactions.In addition to being used as a chip-based infusion source, the instrument can also serve as an LC/MS fraction collector. With the integration of an HPLC system, this mode can better help with mass spectrometry investigations of complex compounds. By setting up the instrument in this mode, samples have better separation and thus have better defined MS peaks. During separation of samples, small amounts are diverted and placed in microplates so that portions of samples can be analyzed in later investigations. This mode increases analytical capabilities by creating a catalogue of all samples that can be referenced for further analysis. With this mode in effect, a single LC/MS run has the ability to yield both quantitative and qualitative results.

This capability is ideal for use in applications such as metabolite identification, top-down proteomics, and investigations in protein biomarkers and post-translational modifications.The third mode utilizes liquid extraction surface analysis (LESA), which is an optional upgrade for any NanoMate system. This feature gives the instrument a capacity to evaluate more analytes with increased sensitivity; LESA makes analyte analysis fast, simple, and direct. Any surface with extractable analytes can be used for analysis, including thin tissue sections, dried blood spots on pieces of paper, and TLC plates.

Was founded in 1993 based on the novel techniques developed within the Cornell University laboratory of Dr. Jack Henion, a leading researcher in the field of Liquid Chromatography/Mass Spectrometry (LC/MS). The company’s vision was to become a leading provider of bioanalytical contract services to the pharmaceutical industry, a position it attained prior to the sale of its contract drug development laboratory business to Quintiles. Pioneers within the industry, Advion offers a variety of mission critical systems and consumables for life science research.

With sales and support offices in North America, Europe, and Japan, Advion is a global company with customers in all of the top pharmaceutical companies, government life science research agencies and universities. Advion continues to expand its diverse portfolio of innovative microfluidic and mass spec – based products for the life science industry.

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